I've got an old Lacie BigDisk lying around which was rendered useless when the internal Fujitsu drives failed to spin up. This morning I decided to re-populate the Lacie with two Maxtor PATA drives.
The drives must be jumpered as Master and Slave. They mounted immediately but only as two distinct volumes, not spanned as originally shipped. This will work fine for my needs but if you want to span them as originally configured by Lacie, you'll need a utility from Oxford Semiconductor.
Take a look at these posts from wwward and Prune's Blog for photos and more details. If you have trouble finding the software mentioned (i.e.: uploadergui.jar) visit my Downloads page.
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